Applied AI Scientist/Researcher (Senior/Staff) - VC Backed Startups

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🌍 Remote📍 NYC - HybridFullTime

About this role

Join SignalFire’s Talent Network for Senior/Staff Applied AI Scientist & Researcher Roles at VC-Backed Startups

🛑 This is not an application for a specific job. Instead, this is a way to get on the radar of VC-backed startups that are actively hiring Applied AI Scientists and Researchers. If you have any questions, please direct inquiries to talentnetwork@signalfire.com.

At SignalFire, we partner with top early-stage startups that are shaping the future of technology. Our portfolio spans 200+ innovative companies across AI, cybersecurity, healthtech, fintech, developer tools, and enterprise SaaS.

We’re looking to connect with exceptional Senior and Staff Applied AI Scientists and Researchers who are excited about developing advanced AI capabilities, solving complex technical problems, and translating emerging research into differentiated products.

By joining SignalFire’s Talent Network, your profile will be shared with our portfolio companies, giving you visibility into exclusive early-stage opportunities that may not be publicly listed.

Who Should Join?

We’re looking for scientists and researchers who are:

✔ Passionate about advancing the capabilities and real-world applications of artificial intelligence
✔ Experienced in developing, adapting, and evaluating modern machine learning models
✔ Excited to translate research and experimentation into production-ready product capabilities
✔ Comfortable operating at the intersection of research, engineering, product, and customer needs
✔ Interested in solving open-ended technical problems in fast-moving startup environments

Typical Roles & Responsibilities

  • Research, develop, and evaluate machine learning methods that improve product capabilities and customer outcomes

  • Design experiments to test new model architectures, training approaches, data strategies, and system designs

  • Adapt foundation models through fine-tuning, post-training, prompt optimization, retrieval, or other techniques

  • Develop evaluation frameworks and benchmarks for model quality, reliability, safety, and performance

  • Build prototypes and proofs of concept that demonstrate the potential of emerging AI techniques

  • Partner with AI/ML engineers and software engineers to translate successful experiments into production systems

  • Improve model accuracy, reasoning, latency, efficiency, robustness, and cost

  • Curate, generate, and evaluate datasets used for training, fine-tuning, and model assessment

  • Investigate model failures, edge cases, and unexpected behavior to identify opportunities for improvement

  • Stay current with relevant research and determine which advances can create practical product value

  • Communicate findings, tradeoffs, and technical recommendations to product, engineering, and executive stakeholders

  • Mentor other scientists and contribute to the company’s research culture, technical standards, and AI roadmap

  • Publish research, contribute to open-source projects, or represent the company within the broader technical community where appropriate

Common Qualifications

While each startup has its own hiring criteria, many Senior and Staff Applied AI Scientist and Researcher roles in our network look for:

  • 5+ years of experience in machine learning, artificial intelligence, applied research, or a related technical field

  • Strong foundation in deep learning, statistics, optimization, and experimental design

  • Experience developing or adapting models for real-world product applications

  • Expertise in one or more areas such as natural language processing, generative AI, computer vision, multimodal learning, reinforcement learning, recommendation systems, or speech

  • Proficiency in Python and modern machine learning frameworks such as PyTorch, TensorFlow, or JAX

  • Experience with model training, fine-tuning, post-training, evaluation, or inference

  • Ability to design rigorous experiments and draw sound conclusions from incomplete or ambiguous results

  • Track record of translating research concepts into prototypes, production systems, or measurable product improvements

  • Ability to collaborate closely with research, engineering, product, and domain experts

  • Strong written and verbal communication skills, including the ability to explain complex technical concepts clearly

  • Staff-level candidates may be expected to define research direction, lead cross-functional initiatives, and influence broader AI strategy

  • Advanced degree in computer science, machine learning, statistics, mathematics, or a related field may be preferred, although equivalent applied experience may be considered

💡 Technologies You Might Work With:

  • Languages & Frameworks: Python, PyTorch, TensorFlow, JAX, Hugging Face, scikit-learn

  • Models & Techniques: Large language models, transformers, multimodal models, diffusion models, reinforcement learning, recommendation and ranking systems

  • Model Adaptation: Fine-tuning, reinforcement learning from feedback, preference optimization, distillation, synthetic data, prompt optimization

  • AI Systems: Retrieval-augmented generation, agents, tool use, structured generation, reasoning systems, model routing

  • Evaluation & Experimentation: Offline and online evaluation, human evaluation, benchmarking, red teaming, interpretability, model observability

  • Data & Infrastructure: Spark, Databricks, Snowflake, vector databases, distributed training, GPUs, Kubernetes

  • Models & Platforms: OpenAI, Anthropic, Google, Meta, open-source foundation models, and proprietary model architectures

What Happens Next?

  1. Submit your application to join SignalFire’s Talent Ecosystem.

  2. We review applications on an ongoing basis to identify strong candidates.

  3. If there’s a match, a SignalFire talent partner or a leader from one of our startups may reach out directly.

  4. No match yet? We’ll keep your profile on file for future Senior and Staff Applied AI Scientist and Researcher roles across our portfolio.

Frequently Asked Questions

Is the salary disclosed for the Applied AI Scientist/Researcher (Senior/Staff) - VC Backed Startups position at signalfire?
The salary for this Applied AI Scientist/Researcher (Senior/Staff) - VC Backed Startups role at signalfire is not publicly listed. Click "Apply Now" to learn more about the compensation package on their official careers page.
Is the Applied AI Scientist/Researcher (Senior/Staff) - VC Backed Startups job at signalfire remote?
Yes, this Applied AI Scientist/Researcher (Senior/Staff) - VC Backed Startups position at signalfire is remote, with team members based in NYC - Hybrid. You can work from home or anywhere in the supported regions.
Is the Applied AI Scientist/Researcher (Senior/Staff) - VC Backed Startups role at signalfire full-time or part-time?
This is listed as a FullTime position. It is posted as a Applied AI Scientist/Researcher (Senior/Staff) - VC Backed Startups role in the EPD department at signalfire.
Which team or department does the Applied AI Scientist/Researcher (Senior/Staff) - VC Backed Startups at signalfire belong to?
This Applied AI Scientist/Researcher (Senior/Staff) - VC Backed Startups position is part of the EPD department at signalfire. See the full job description for more information about the team structure and responsibilities.
How do I apply for the Applied AI Scientist/Researcher (Senior/Staff) - VC Backed Startups position at signalfire?
Click the "Apply Now" button on this page. You will be redirected to signalfire's official application portal hosted on ashby where you can submit your application directly.
When was the Applied AI Scientist/Researcher (Senior/Staff) - VC Backed Startups job at signalfire posted?
This Applied AI Scientist/Researcher (Senior/Staff) - VC Backed Startups position at signalfire was posted on Aug 5, 2026. Apply as soon as possible — early applications are often reviewed first.
Applied AI Scientist/Researcher (Senior/Staff) - VC Backed Startups
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