Associate Director, CMC Regulatory

lyellimmunopharma· Regulatory Affairs
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📍 Seattle, Washington, United States💰 USD 190K–230K

About this role

 

Using living cells to treat – and sometimes even cure – cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. And for patients with hematologic malignancies, there is a need for next-generation cell therapies that can deliver increased response rates and longer duration of response.  We are a clinical-stage company advancing a pipeline of next-generation CAR T-cell therapies for patients with solid tumors or hematologic malignancies. Lyell’s product candidates are enhanced with novel technology designed to generate T cells that resist exhaustion and have qualities of durable stemness in order to drive durable tumor cytotoxicity and achieve consistent and long-lasting clinical response. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. In our quest to advance next-generation CAR T-cell therapies, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency. 

 
The incumbent will be responsible for providing CMC regulatory expertise through all stages of products lifecycle. This role will support CMC Regulatory Affairs interacting with the FDA and will represent CMC Regulatory on CMC and Regulatory Submission Teams, create timelines and drive the submission plan for Quality Modules.

KEY ROLE AND RESPONSIBILITIES:
  • Provide phase-appropriate guidance related to CMC regulatory requirements and expectations for cell therapy development
  • Ensure timely escalation of critical issues to senior management by leading CMC regulatory risk assessment, identifying key CMC regulatory issues and mitigation activities needed throughout product life cycle
  • Collaborate with CMC colleagues to develop CMC content for original INDs, IND amendments, investigational medicinal product dossiers (IMPD) for inclusion in Clinical Trial Applications (CTA) and BLA/MAA
  • Participate in multidisciplinary efforts to prepare CMC updates for regulatory documents including Investigator Brochures, Annual Reports and premeeting meeting packages for Regulatory Authority meetings
  • Coordinate, manage CMC regulatory projects including management of submission timelines, ensuring that CMC-related changes are reported in a timely manner to health authorities in accordance with regulatory requirements
  • Maintain knowledge of the regulatory environment, regulations, and procedures. Identify CMC regulatory opportunity and risks across development lifecycle
  • Partner with key stakeholders in developing tools, templates, and company-wide best practices for CMC regulatory of cell & gene therapies

PREFERRED EDUCATION:

  • MSc or PhD within a scientific or related discipline

PREFERRED EXPERIENCE:

  • A minimum of 8 years of experience in CMC regulatory affairs
  • Experienced in leading CMC regulatory documentation and CMC lifecycle management from IND to marketing applications within the pharmaceutical or biotechnology industry
  • Experience with cell therapy is desirable
  • Global regulatory experience is preferred but not required
  • Minimum 2 years management experience is preferred

KNOWLEDGE, SKILLS AND ABILITIES:

  • Knowledge of FDA, EMA and ICH CMC regulations and guidelines for cell therapies
  • Proven track record in preparing, reviewing and executing CMC regulatory documents to support clinical studies and marketing applications
  • Strong oral and written communication skills
  • Demonstrated ability to develop/maintain strong working relationships with the CMC team and cross-functional teams
  • Ability to multi-task as needed in a fast-paced start-up environment
  • Detail-oriented while also retaining the ability to see the big picture.
  • Familiarity with AI-assisted tools for regulatory writing and document drafting (e.g., large language models), with sound judgment on appropriate use, human oversight, and QC of AI-generated content in submission-ready materials.
 
The salary range for this position is $190,000 to $230,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan. 
 
At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
 
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.

 

 

 

Frequently Asked Questions

What is the salary for the Associate Director, CMC Regulatory role at lyellimmunopharma?
The listed salary for this Associate Director, CMC Regulatory position at lyellimmunopharma is USD 190K–230K. This is an full-time role.
Where is the Associate Director, CMC Regulatory position at lyellimmunopharma located?
This Associate Director, CMC Regulatory role at lyellimmunopharma is based in Seattle, Washington, United States. The position is listed as on-site or hybrid. Check the full job description or apply directly to confirm the work arrangement.
Which team or department does the Associate Director, CMC Regulatory at lyellimmunopharma belong to?
This Associate Director, CMC Regulatory position is part of the Regulatory Affairs department at lyellimmunopharma. See the full job description for more information about the team structure and responsibilities.
How do I apply for the Associate Director, CMC Regulatory position at lyellimmunopharma?
Click the "Apply Now" button on this page. You will be redirected to lyellimmunopharma's official application portal hosted on greenhouse where you can submit your application directly.
When was the Associate Director, CMC Regulatory job at lyellimmunopharma posted?
This Associate Director, CMC Regulatory position at lyellimmunopharma was posted on Aug 21, 2026. Apply as soon as possible — early applications are often reviewed first.
Associate Director, CMC Regulatory
lyellimmunopharma · 💰 USD 190K–230K
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