Senior Endpoint Systems Engineer (HYBRID: Chicago)

tempus· Tempus AI, Inc.
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📍 ChicagoFull time💰 USD 130K–145K
Full timeTempus AI, Inc.

About this role

Passionate about precision medicine and advancing the healthcare industry?

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.

Location: Hybrid: Chicago (3 days on-site)

Position Overview:

We are seeking a highly skilled and strategic Senior Endpoint Systems Engineer to join our IT team. In this role, you will serve as the primary architect and technical lead for the health, security, compliance, and lifecycle management of our global endpoint fleet.
Our environment features a balanced mix of both Windows and macOS devices. We need a senior professional with deep, dual-platform expertise who can design scalable deployment workflows, architect robust endpoint security configurations, and optimize our enterprise toolset—specifically Microsoft Intune, Jamf Pro, and Workspace ONE. As a senior member of the team, you will drive technical strategy, lead complex integration projects, and mentor junior IT staff to ensure a seamless and secure digital employee experience.

Key Responsibilities:
  • Enterprise MDM Architecture: Architect, optimize, and maintain our global Unified Endpoint Management (UEM) infrastructure using Microsoft Intune, Jamf Pro, and VMware Workspace ONE.
  • Strategic Fleet Engineering: Design and scale automated deployment, provisioning, and configuration management workflows for a balanced fleet of Windows 10/11 and macOS hardware.
  • Modern Provisioning & Lifecycle: Standardize and evolve modern deployment frameworks utilizing Windows Autopilot, Apple Business Manager (ABM), and Automated Device Enrollment to achieve zero-touch provisioning.
  • Advanced Scripting & Automation: Develop, test, and maintain robust code repositories (PowerShell for Windows; Bash/Zsh/Python for macOS) to automate complex administrative tasks, custom reporting, and API integrations.
  • Security & Compliance Governance: Partner closely with the Security team to engineer and enforce endpoint security baselines (e.g., CIS Benchmarks), disk encryption protocols (BitLocker, FileVault), and EDR/antivirus agent deployments.
  • Identity & Access Architecture: Lead the integration of endpoint platforms with enterprise identity and access management (IAM) systems (e.g., Entra ID, Okta), including modern single sign-on (SSO) extensions.
  • Tier 3/4 Escalation & Mentorship: Act as the highest tier of technical escalation for complex endpoint, OS, and software issues. Provide mentorship, guidance, and technical training to Tier 1/2 service desk and junior systems administrators.
  • Roadmapping & Documentation: Maintain a forward-looking roadmap for endpoint technologies, evaluate emerging tools, and author authoritative architectural diagrams and standard operating procedures (SOPs).

Required Skills & Qualifications:
  • Experience: 5–8+ years of dedicated experience in endpoint engineering, systems administration, or infrastructure architecture within an enterprise environment.
  • Dual-Platform Mastery: Comprehensive, expert-level knowledge of both Windows and macOS operating systems, system internals, and enterprise deployment methodologies.
  • Enterprise Tooling Expertise: Deep hands-on engineering experience configuring and managing Microsoft Intune, Jamf Pro, and Workspace ONE at scale.
  • Advanced Scripting: Strong proficiency in PowerShell and Bash/Zsh (Python or Swift is a significant plus) for advanced automation, custom scripts, and utilizing MDM APIs.
  • Leadership & Communication: Proven ability to lead projects independently, collaborate across multi-functional engineering teams, and explain complex technical concepts to non-technical stakeholders.

$130,000-$145,000 annually

The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.

We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. 

Frequently Asked Questions

What is the salary for the Senior Endpoint Systems Engineer (HYBRID: Chicago) role at tempus?
The listed salary for this Senior Endpoint Systems Engineer (HYBRID: Chicago) position at tempus is USD 130K–145K. This is an Full time role.
Where is the Senior Endpoint Systems Engineer (HYBRID: Chicago) position at tempus located?
This Senior Endpoint Systems Engineer (HYBRID: Chicago) role at tempus is based in Chicago. The position is listed as on-site or hybrid. Check the full job description or apply directly to confirm the work arrangement.
Is the Senior Endpoint Systems Engineer (HYBRID: Chicago) role at tempus full-time or part-time?
This is listed as a Full time position. It is posted as a Senior Endpoint Systems Engineer (HYBRID: Chicago) role in the Tempus AI, Inc. department at tempus.
Which team or department does the Senior Endpoint Systems Engineer (HYBRID: Chicago) at tempus belong to?
This Senior Endpoint Systems Engineer (HYBRID: Chicago) position is part of the Tempus AI, Inc. department at tempus. See the full job description for more information about the team structure and responsibilities.
How do I apply for the Senior Endpoint Systems Engineer (HYBRID: Chicago) position at tempus?
Click the "Apply Now" button on this page. You will be redirected to tempus's official application portal hosted on workday where you can submit your application directly.
When was the Senior Endpoint Systems Engineer (HYBRID: Chicago) job at tempus posted?
This Senior Endpoint Systems Engineer (HYBRID: Chicago) position at tempus was posted on Jul 10, 2026. Apply as soon as possible — early applications are often reviewed first.
Senior Endpoint Systems Engineer (HYBRID: Chicago)
tempus · 💰 USD 130K–145K
Apply for this role ↗

You'll be redirected to tempus's official application page on Workday.